I am very much appreciate for your work on HUMAnN.
I used to use HUMAnN 2.0 to get community profiling, and it works fine. Recently, I have HUMAnN 3.0 installed since the HUMAnN 3.0 is available. I have run HUMAnN2 and HUMAnN3 using the same dataset, finding that there are lots of differences, both in taxonomy and pathway, especially in low abundance. And the correlation(spearman and person) of HUMAnN2 and HUMAnN3 is not much high as wished.
These results have confused me a lot, I don’t know which result is close to the real data. So, have you done any benchmarking analysis about HUMAnN3? And does it reasonable for such lots of differences?