Microbiota from MetaPhlan3 was disticnt with Humman2

Microbial community profiling MetaPhlAn
1

Hi,

I profiled the microbial community using metaphlan 3, then adopted humman2 to do the pathway enrichment and genefamilies enrichment. But I found some bacteria that the genes were assigned to were not detected by metaphlan3, what happened? This discrepancy was derived from the databases between metaphlan 3 and humann2? Which one should I trust?

Cheers,
Dengwei

2

Hey, have you solved this problem?

3

I have the same problem here. Is there any update?