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MelonnPan Input - Picrust2 output

Hello,

I am a MelonnPan user. Does Melonnpan accept the output from Picrust2? If Melonnpan accepts Picrust2 output, then how do I convert the KO gene IDs (produced by Picrust2) to their respective Uniref90 IDs (input format of Melonnpan) ? Thank you in advance.

Best regards,

Ilaria

It is not possible to convert KOs to UniRef90s since that mapping is 1 to many. You would want to train a MelonnPan model on metagenomic KOs as the predictors and then use that model with PICRUSt-predicted KOs to predict metabolites. You can convert UniRef90s to KOs using the humann2_regroup_table script.

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