I am a MelonnPan user. Does Melonnpan accept the output from Picrust2? If Melonnpan accepts Picrust2 output, then how do I convert the KO gene IDs (produced by Picrust2) to their respective Uniref90 IDs (input format of Melonnpan) ? Thank you in advance.
It is not possible to convert KOs to UniRef90s since that mapping is 1 to many. You would want to train a MelonnPan model on metagenomic KOs as the predictors and then use that model with PICRUSt-predicted KOs to predict metabolites. You can convert UniRef90s to KOs using the