Hi @carli-jones - this topic has been discussed here: MelonnPan Input - Picrust2 output.
In short, currently, it is not possible to use Picrust/Picrust2 KO output with the default MelonnPan-Predict module. However, the users can still use the MelonnPan-Train module to train a new model with KOs derived from Picrust/Picrust2.