EC numbers and bacteria


I have question regarding the use of utility mapping data in HUMAnN. My primary goal is to establish links between EC numbers and bacteria using HUMAnN’s utility mapping, instead of using external dataset. Is there a way to obtain a priori knowledge of the connections between ECs and bacteria using HUMAnN 3.0?

Thank you!


One way to do this would be to list the UniRef90s that are associated to each bacterial species in HUMAnN’s pangenome database (based on their occurrence in the FASTA headers of that species’ genes). Then, you can compare these lists to the mapping from ECs to UniRef90s in HUMAnN’s utility mapping to associate species with ECs.