Using Maaslin2 with centered log ratio transformation

Hi @jjsimz,

I believe CLR is an option in MaAsLin 2, see here under the normalization section. Therefore, if you have already CLR normalized your data, yes your suggestions above should work just fine under the hood.

This post, also includes a bit more information on the different methods that MaAsLin has available.

I hope this helps!
Best,
Kelsey