Uniref90 Gene Families to Pathways


I’ve created tables for UniRef90 gene families and UniRef Pathways and I’m wondering if there’s a way to link these two. In general I’m looking for some sort of mapping file that says which gene families are part of which pathways.


You’d have to do this as a two-step process. Under the HUMAnN pathway data folder, you’ll find a file that maps gene families (UniRefs) to MetaCyc reactions:


And then there is a separate file that defines pathways according to their component reactions and arrangement:


You can consider that a gene family contributes to a detected pathway if it maps to a RXN that is included in that pathway’s definition.

The files above can also be found here: