Is it possible to weight samples by read depth


I have some taxonomic microbiome data that I would like to weight each sample based on the sequencing depth of that sample.

Is there any native way to do this?


Hi @Sam_McMillan ,

There is no current way to “weight” samples by read depth but there are few different normalization options that attempt to deal with differing read depths in various ways. You can check out the MaAsLin2 paper for more info:

Jacob Nearing