Very cool software! I’ve always wanted to compare methods myself but the task seemed to daunting! I believe that it’s important to find a statistical model that works best for a data structure and design similar to one’s own data.
Would it be feasible to simulate data based on the pathway-sample table generated from humann2? Could I simply reformat my pathway table into a QIIME OTU table format and have SparseDOSSA simulate data based on it or is the nature of the pathway data too different from microbiota OTU/ASV type data?