I am using MaAslin2 for the microbiota features wide association analysis. But I found that MaAslin2 performs the FDR adjustment for all the included covariates rather than just focusing on the one variable of interest.
In this way, is the default FDR adjustment in MaAslin2 somewhat over-adjustment?
I attached the codes I used below to show my observations.
Looking forward to hearing from your guys’ reply.
FDR adjustment in MaAslin2.txt (2.5 KB)