Description: MetaWIBELE ( W orkflow to I dentify novel B ioactive Ele ments in the microbiome) is a workflow to efficiently and systematically identify uncharacterized microbial community gene products with potential bioactivity. It prioritizes candidate gene products from assembled metagenomes using a combination of sequence homology, secondary-structure-based functional annotations, phylogenetic binning, ecological distribution, and phenotypic population statistics to target candidate bioactives linked to phenotypes such as IBD. MetaWIBELE is available as module of bioBakery bioBakery repository.
A manuscript describing MetaWIBELE is currently in prep:
Identifying Novel Bioactive Microbial Gene Products in Inflammatory Bowel Disease
And feel free to link to MetaWIBELE in your Methods: